This plot shows the distribution (blue) of single-mutant fitness measurements for the gene-of-interest across all isogenic HAP1 screens, measured as log₂(fold-change) at the end-point vs. T₀. This is overlaid on reference distributions of gold-standard essential genes (furthest left), gold-standard non-essential genes (centered on zero), positive fitness effect (right shift), and non-essential fitness genes (left shift). There are also summaries of the number of screens where the gene is “essential”, and the fitness class that the gene falls into. Plots are shown for GIN screens as well as DepMap.

Scatterplot showing the change in fitness due to gene knockout in wild-type HAP1 cells (x-axis) vs an isogenic query cell line. Significant negative genetic interactions are shown in blue, positive genetic interactions in yellow. The gene-of-interest is shown as a red point.

Scatterplot shows the qGI score (y-axis) for the gene of interest across all of the query cell lines screened (x-axis). The top 10 most extreme points are labelled, but you can mouse over individual points to see metrics such as qGI score and FDR, rank, and the exact screen ID. Dotted lines indicate threshold for being considered a stringent hit.

Scatterplot that shows the qGI values for the gene-of-interest (x-axis) and a gene chosen from the table of top correlated genes (y-axis) across all 298 query screens. Points are coloured according to their molecular function category.